Assay Detail
Binding
CHEMBL861694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cobalt substituted Escherichia coli LuxS
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
S-ribosylhomocysteine lyase (CHEMBL3496) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.20 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207406 | — | — | 1 | 5.50 |
| CHEMBL208091 | — | — | 1 | 4.90 |
| CHEMBL206556 | — | — | 1 | - |
| CHEMBL117442 | — | — | 1 | - |
| CHEMBL206725 | — | — | 1 | - |
| CHEMBL438441 | — | — | 1 | - |
| CHEMBL379182 | — | — | 1 | - |
| CHEMBL42336 | METHIONINE | 3.0 | 1 | - |
| CHEMBL208235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207406 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL208091 | — | Ki | = | 12700.0 | nM | 4.90 |
| CHEMBL206556 | — | Ki | - | — | - | |
| CHEMBL117442 | — | Ki | = | 720000.0 | nM | - |
| CHEMBL206725 | — | Ki | - | — | - | |
| CHEMBL438441 | — | Ki | - | — | - | |
| CHEMBL379182 | — | Ki | - | — | - | |
| CHEMBL42336 | METHIONINE | Ki | - | — | - | |
| CHEMBL208235 | — | Ki | - | — | - |