Assay Detail
Binding
CHEMBL862180
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Inhibition of PTP1B
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Protein tyrosine phosphatase 1B inhibitors from Morus root bark.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.37 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382338 | SANGGENON G | — | 1 | 5.80 |
| CHEMBL204813 | SANGGENON C | — | 1 | 5.58 |
| CHEMBL378806 | MULBERROFURAN C | — | 1 | 5.31 |
| CHEMBL377937 | KUWANON L | — | 1 | 4.77 |
| CHEMBL426373 | — | — | 1 | - |
| CHEMBL561971 | MORACIN P | — | 1 | - |
| CHEMBL205924 | MORACIN O | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382338 | SANGGENON G | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL204813 | SANGGENON C | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL378806 | MULBERROFURAN C | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL377937 | KUWANON L | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL426373 | — | IC50 | = | 4500.0 | nM | - |
| CHEMBL561971 | MORACIN P | IC50 | > | 80000.0 | nM | - |
| CHEMBL205924 | MORACIN O | IC50 | > | 80000.0 | nM | - |