Compound Detail
CHEMBL382338
SANGGENON G Enter ChEMBL ID:
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CC(C)=CCCC1=C[C@H](c2c(O)cc3c(c2O)C(=O)C[C@@H](c2cc(O)ccc2O)O3)[C@@H](C(=O)c2ccc(O)cc2O)[C@H](c2ccc(O)cc2O)C1
Basic Information
| ChEMBL ID | CHEMBL382338 |
| Name | SANGGENON G |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZXTQHAMOONDJDJ-YTAXAHCSSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
694.7
MW (Da)
7.48
ALogP
11
HBA
8
HBD
205.2
PSA (Ų)
0.05
QED
4
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 CHEMBL335 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.75 | 4.75 | 17800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 | IC50 | = | 1600.0 | nM | 5.8 | Inhibition of PTP1B | 16356713 |
| Unchecked | IC50 | = | 17800.0 | nM | 4.75 | Inhibition of PP1 | 16356713 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16356713 | 10.1016/j.bmcl.2005.11.071 | Tyrosine-protein phosphatase non-receptor type 1 | 1 |
| 16356713 | 10.1016/j.bmcl.2005.11.071 | Dual specificity protein phosphatase 3 | 1 |
| 16356713 | 10.1016/j.bmcl.2005.11.071 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine