Assay Detail
Binding
CHEMBL862304
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Inhibition of serotonin re-uptake at human serotonin transporter expressed in HEK293 cells
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206697 | — | — | 1 | 9.00 |
| CHEMBL383706 | — | — | 1 | 9.00 |
| CHEMBL411693 | — | — | 1 | 8.70 |
| CHEMBL438257 | — | — | 1 | 8.70 |
| CHEMBL382810 | — | — | 1 | 8.70 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 8.52 |
| CHEMBL203741 | — | — | 1 | 8.52 |
| CHEMBL378379 | — | — | 1 | 8.52 |
| CHEMBL381792 | — | — | 1 | 8.52 |
| CHEMBL383427 | — | — | 1 | 8.40 |
| CHEMBL381754 | — | — | 1 | 8.30 |
| CHEMBL439337 | — | — | 1 | 8.30 |
| CHEMBL203776 | — | — | 1 | 8.30 |
| CHEMBL380758 | — | — | 1 | 8.30 |
| CHEMBL206649 | — | — | 1 | 8.22 |
| CHEMBL206211 | — | — | 1 | 8.22 |
| CHEMBL204285 | — | — | 1 | 8.22 |
| CHEMBL205505 | — | — | 1 | 8.15 |
| CHEMBL382241 | — | — | 1 | 8.15 |
| CHEMBL205837 | — | — | 1 | 8.10 |
| CHEMBL380523 | — | — | 1 | 8.05 |
| CHEMBL203674 | — | — | 1 | 8.00 |
| CHEMBL206598 | — | — | 1 | 8.00 |
| CHEMBL383081 | — | — | 1 | 7.89 |
| CHEMBL202907 | — | — | 1 | 7.62 |
| CHEMBL206599 | — | — | 1 | 7.60 |
| CHEMBL382673 | — | — | 1 | 7.60 |
| CHEMBL378804 | — | — | 1 | 7.52 |
| CHEMBL206404 | — | — | 1 | 7.51 |
| CHEMBL204005 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206697 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL383706 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL438257 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL382810 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL411693 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL809 | SERTRALINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL203741 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL378379 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL381792 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL383427 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL439337 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL380758 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL203776 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL381754 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL204285 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL206649 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL206211 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL205505 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL382241 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL205837 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL380523 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL206598 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL203674 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL383081 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL202907 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL206599 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL382673 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL378804 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL206404 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL204005 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL203453 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL202910 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL381315 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL203236 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL202755 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL383128 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL203331 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL204323 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL202810 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL381331 | — | IC50 | > | 1000.0 | nM | - |