Assay Detail
Functional
CHEMBL862406
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Antiproliferative activity against human A2780 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel combretastatin analogues endowed with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.20 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.66 |
| CHEMBL210722 | — | — | 1 | 7.30 |
| CHEMBL210806 | — | — | 1 | 7.16 |
| CHEMBL379473 | — | — | 1 | 6.58 |
| CHEMBL382453 | — | — | 1 | 6.30 |
| CHEMBL378110 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.19 | nM | 8.66 |
| CHEMBL210722 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL210806 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL379473 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL382453 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL378110 | — | IC50 | - | — | - |