Assay Detail
Functional
CHEMBL862407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against doxorubicin-resistant human A2780-dx cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel combretastatin analogues endowed with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.24 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.78 |
| CHEMBL378110 | — | — | 1 | 7.66 |
| CHEMBL210722 | — | — | 1 | 7.34 |
| CHEMBL210806 | — | — | 1 | 7.02 |
| CHEMBL379473 | — | — | 1 | 6.54 |
| CHEMBL382453 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.66 | nM | 8.78 |
| CHEMBL378110 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL210722 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL210806 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL379473 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL382453 | — | IC50 | = | 750.0 | nM | 6.12 |