Assay Detail
Functional
CHEMBL862905
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Antiproliferative activity against human HL60 cell line
53
Total Activities
49
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.21 | 6.30 |
| TGI | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455983 | — | — | 1 | 6.30 |
| CHEMBL376752 | — | — | 1 | 6.10 |
| CHEMBL377894 | — | — | 1 | 6.00 |
| CHEMBL211397 | — | — | 1 | 6.00 |
| CHEMBL292687 | DINITROCHLOROBENZENE | 1.0 | 1 | 5.85 |
| CHEMBL209865 | — | — | 1 | 5.82 |
| CHEMBL210398 | — | — | 1 | 5.66 |
| CHEMBL213694 | — | — | 1 | 5.62 |
| CHEMBL212587 | — | — | 1 | 5.50 |
| CHEMBL212378 | — | — | 2 | 5.47 |
| CHEMBL211333 | — | — | 1 | 5.46 |
| CHEMBL211413 | — | — | 2 | 5.46 |
| CHEMBL379147 | — | — | 2 | 5.46 |
| CHEMBL212060 | — | — | 1 | 5.44 |
| CHEMBL212676 | — | — | 2 | 5.43 |
| CHEMBL209533 | — | — | 1 | 5.43 |
| CHEMBL211651 | — | — | 1 | 5.41 |
| CHEMBL211403 | — | — | 1 | 5.40 |
| CHEMBL209687 | — | — | 1 | 5.36 |
| CHEMBL535162 | — | — | 1 | 5.30 |
| CHEMBL213693 | — | — | 1 | 5.28 |
| CHEMBL212634 | — | — | 1 | 5.23 |
| CHEMBL436743 | — | — | 1 | 5.20 |
| CHEMBL378034 | — | — | 1 | 5.17 |
| CHEMBL211724 | — | — | 1 | 5.14 |
| CHEMBL213455 | — | — | 1 | 5.14 |
| CHEMBL209697 | — | — | 1 | 5.13 |
| CHEMBL211833 | — | — | 1 | 5.09 |
| CHEMBL213947 | — | — | 1 | 5.08 |
| CHEMBL213851 | N-(ETHOXYCARBONYL)PIPERAZINE | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455983 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL376752 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL211397 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL377894 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL292687 | DINITROCHLOROBENZENE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL209865 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL210398 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL213694 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL212587 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL212378 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL211333 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL379147 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL211413 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL212060 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL209533 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL212676 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL211651 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL211403 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL209687 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL535162 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL213693 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL212634 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL436743 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL378034 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL213455 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL211724 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL209697 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL211833 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL213947 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL213757 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL213851 | N-(ETHOXYCARBONYL)PIPERAZINE | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL211675 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL211436 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL202300 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL378531 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL377105 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL209095 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL211834 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1412 | PIPERAZINE | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL93268 | SODIUM NITRITE | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL377903 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL273386 | 2,4-DINITROPHENOL | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL211413 | — | TGI | = | 8300.0 | nM | - |
| CHEMBL209698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL212676 | — | TGI | = | 8100.0 | nM | - |
| CHEMBL379147 | — | TGI | = | 57500.0 | nM | - |
| CHEMBL211805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL212623 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL211900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL212378 | — | TGI | > | 100000.0 | nM | - |