Compound Detail
CHEMBL93268
SODIUM NITRITE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL93268 |
| Name | SODIUM NITRITE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | LPXPTNMVRIOKMN-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1161681 |
| Active Moiety | CHEMBL1161681 |
1
Targets
71
Activities
2
Assay Types
0
PK Parameters
20
Publications
10
Known Names
18
Indications
Molecular Properties
47.0
MW (Da)
0.14
ALogP
2
HBA
1
HBD
49.7
PSA (Ų)
0.31
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2011 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Poisoning Acute Kidney Injury Aging Anemia, Sickle Cell Asthma Diabetes Mellitus Heart Arrest Heart Failure Hypertension, Pulmonary Hypertension, Pulmonary Myocardial Infarction Peripheral Arterial Disease Renal Insufficiency, Chronic ST Elevation Myocardial Infarction Subarachnoid Hemorrhage Cystic Fibrosis Hypertension Malaria, Falciparum
ATC Classification
V03AB08
sodium nitrite
Level 1: VARIOUS
Level 2: ALL OTHER THERAPEUTIC PRODUCTS
Drug Warnings
Black Box Warning
hematological toxicity
Black Box Warning
vascular toxicity
Activity Summary
Ki 70 meas.
IC50 1 meas. best 4.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HL-60 CHEMBL383 | IC50 | 4.03 | 4.03 | 94000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HL-60 | IC50 | = | 94000.0 | nM | 4.03 | Antiproliferative activity against human HL60 cell line | 16821795 |
Literature References
Data from ChEMBL 36 via Core Engine