Assay Detail
Functional
CHEMBL863219
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Antiproliferative activity against human A2780 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A practical synthesis of the major 3-hydroxy-2-pyrrolidinone metabolite of a potent CDK2/cyclin A inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.85 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191144 | — | — | 1 | 6.10 |
| CHEMBL380280 | — | — | 1 | 5.80 |
| CHEMBL381986 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191144 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL380280 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL381986 | — | IC50 | = | 2200.0 | nM | 5.66 |