Assay Detail
Binding
CHEMBL863373
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Displacement of [3H]deltorphin II from delta opioid receptor in rat brain membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.53 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380590 | — | — | 1 | 9.89 |
| CHEMBL372130 | — | — | 1 | 9.64 |
| CHEMBL198909 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380590 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL372130 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL198909 | — | Ki | = | 0.89 | nM | 9.05 |