Assay Detail
Binding
CHEMBL863411
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Inhibition of [125I]DOI binding to 5HT2A receptor in rat cerebral cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.92 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134519 | — | — | 1 | 9.68 |
| CHEMBL373245 | — | — | 1 | 9.27 |
| CHEMBL371300 | — | — | 1 | 9.24 |
| CHEMBL197653 | — | — | 1 | 9.14 |
| CHEMBL200104 | — | — | 1 | 9.13 |
| CHEMBL199385 | — | — | 1 | 9.11 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 9.03 |
| CHEMBL201132 | — | — | 1 | 8.78 |
| CHEMBL199775 | — | — | 1 | 8.72 |
| CHEMBL31115 | — | — | 1 | 8.70 |
| CHEMBL437314 | — | — | 1 | 8.68 |
| CHEMBL275854 | — | — | 1 | 8.46 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134519 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL373245 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL371300 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL197653 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL200104 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL199385 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL39 | SEROTONIN | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL201132 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL199775 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL31115 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL437314 | — | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL275854 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL7257 | MEBUFOTENIN | IC50 | = | 9.53 | nM | 8.02 |