Assay Detail
ADMET
CHEMBL863594
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Inhibition of CYP2D6 in human liver microsomes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.97 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219128 | — | — | 1 | 5.16 |
| CHEMBL220407 | — | — | 1 | 4.77 |
| CHEMBL218834 | — | — | 1 | - |
| CHEMBL218410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219128 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL220407 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL218834 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL218410 | — | IC50 | > | 25000.0 | nM | - |