Assay Detail
Binding
CHEMBL863645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPA
25
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.75 | 10.00 |
| Ki | 1 | 8.33 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214322 | — | — | 1 | 10.00 |
| CHEMBL215819 | — | — | 1 | 8.85 |
| CHEMBL386247 | — | — | 1 | 8.70 |
| CHEMBL216010 | — | — | 1 | 8.70 |
| CHEMBL386117 | — | — | 1 | 8.70 |
| CHEMBL216192 | — | — | 2 | 8.33 |
| CHEMBL385831 | — | — | 1 | 8.05 |
| CHEMBL215418 | — | — | 1 | 7.96 |
| CHEMBL214280 | — | — | 1 | 7.82 |
| CHEMBL373886 | — | — | 1 | 6.85 |
| CHEMBL214442 | — | — | 1 | 6.77 |
| CHEMBL424720 | — | — | 1 | 6.48 |
| CHEMBL373887 | — | — | 1 | 6.47 |
| CHEMBL214535 | — | — | 1 | 6.42 |
| CHEMBL215958 | — | — | 1 | 6.27 |
| CHEMBL215841 | — | — | 1 | - |
| CHEMBL214177 | — | — | 1 | - |
| CHEMBL215279 | — | — | 1 | - |
| CHEMBL216561 | — | — | 1 | - |
| CHEMBL265132 | — | — | 1 | - |
| CHEMBL384247 | — | — | 1 | - |
| CHEMBL384626 | — | — | 1 | - |
| CHEMBL386968 | — | — | 1 | - |
| CHEMBL385215 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214322 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL215819 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL386247 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL216010 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL386117 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL216192 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL216192 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL385831 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL215418 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL214280 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL373886 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL214442 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL424720 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL373887 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL214535 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL215958 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL214177 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL215279 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL216561 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL265132 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL215841 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL384247 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL384626 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL386968 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL385215 | — | IC50 | > | 1000.0 | nM | - |