Compound Detail
CHEMBL373886
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Cc1ccc(Oc2ccc(C(=O)NCCN3CCCC3)cc2NC(=O)Nc2ccc(-c3ccccc3)cc2)cc1C
Basic Information
| ChEMBL ID | CHEMBL373886 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NOHYKQAGOKRKCR-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
548.7
MW (Da)
7.23
ALogP
4
HBA
3
HBD
82.7
PSA (Ų)
0.21
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL1075228 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL4730 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 140.0 | nM | 6.85 | Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-S... | 16887348 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 260.0 | nM | 6.58 | Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPA | 16887348 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 400.0 | nM | 6.4 | Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-S... | 16887348 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16887348 | 10.1016/j.bmcl.2006.07.040 | Melanin-concentrating hormone receptor 1 | 3 |
Data from ChEMBL 36 via Core Engine