Compound Detail
CHEMBL424720
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Basic Information
| ChEMBL ID | CHEMBL424720 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKKMHIDCPGJNCQ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
485.6
MW (Da)
5.49
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.40
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL1075228 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL4730 | IC50 | 6.21 | 6.21 | 610.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 250.0 | nM | 6.6 | Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPA | 16887348 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 330.0 | nM | 6.48 | Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-S... | 16887348 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 610.0 | nM | 6.21 | Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-S... | 16887348 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16887348 | 10.1016/j.bmcl.2006.07.040 | Melanin-concentrating hormone receptor 1 | 3 |
Data from ChEMBL 36 via Core Engine