Assay Detail
Binding
CHEMBL864025
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Inhibition of AchE from bovine erythrocytes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.25 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381499 | — | — | 1 | 9.70 |
| CHEMBL199670 | — | — | 1 | 9.00 |
| CHEMBL199585 | — | — | 1 | 8.70 |
| CHEMBL383663 | — | — | 1 | 8.70 |
| CHEMBL382260 | — | — | 1 | 8.64 |
| CHEMBL199538 | — | — | 1 | 8.46 |
| CHEMBL199861 | — | — | 1 | 8.40 |
| CHEMBL372202 | — | — | 1 | 8.30 |
| CHEMBL199454 | — | — | 1 | 8.05 |
| CHEMBL199748 | — | — | 1 | 7.92 |
| CHEMBL200008 | — | — | 1 | 7.60 |
| CHEMBL370807 | — | — | 1 | 7.46 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL202661 | — | — | 1 | 7.19 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381499 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL199670 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL199585 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL383663 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL382260 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL199538 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL199861 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL372202 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL199454 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL199748 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL200008 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL370807 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL95 | TACRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL202661 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL45 | MELATONIN | IC50 | > | 100.0 | nM | - |