Assay Detail
Binding
CHEMBL864026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.11 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372202 | — | — | 1 | 10.40 |
| CHEMBL381499 | — | — | 1 | 10.00 |
| CHEMBL370807 | — | — | 1 | 9.35 |
| CHEMBL199670 | — | — | 1 | 9.30 |
| CHEMBL382260 | — | — | 1 | 9.19 |
| CHEMBL202661 | — | — | 1 | 9.06 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.46 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
| CHEMBL199585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372202 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL381499 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL370807 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL199670 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL382260 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL202661 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL95 | TACRINE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL45 | MELATONIN | IC50 | - | — | - | |
| CHEMBL199585 | — | IC50 | = | 0.008 | nM | - |