Assay Detail
Binding
CHEMBL864029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BuChE
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.99 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370807 | — | — | 1 | 9.00 |
| CHEMBL382260 | — | — | 1 | 8.52 |
| CHEMBL199670 | — | — | 1 | 8.17 |
| CHEMBL199585 | — | — | 1 | 8.11 |
| CHEMBL202661 | — | — | 1 | 7.64 |
| CHEMBL372202 | — | — | 1 | 7.60 |
| CHEMBL381499 | — | — | 1 | 7.46 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370807 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL382260 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL199670 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL199585 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL202661 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL372202 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL381499 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL95 | TACRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL45 | MELATONIN | IC50 | - | — | - |