Assay Detail
Functional
CHEMBL864160
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Inhibition of IL2 production in Jurkat T cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.03 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208901 | — | — | 1 | 6.68 |
| CHEMBL208846 | — | — | 1 | 6.64 |
| CHEMBL209163 | — | — | 1 | 6.60 |
| CHEMBL209148 | — | — | 1 | 6.60 |
| CHEMBL209881 | — | — | 1 | 6.58 |
| CHEMBL379114 | — | — | 1 | 6.55 |
| CHEMBL380058 | — | — | 1 | 6.44 |
| CHEMBL210248 | — | — | 1 | 6.43 |
| CHEMBL211291 | — | — | 1 | 6.38 |
| CHEMBL379478 | — | — | 1 | 6.34 |
| CHEMBL211842 | — | — | 1 | 6.16 |
| CHEMBL382362 | — | — | 1 | 6.16 |
| CHEMBL210932 | — | — | 1 | 6.00 |
| CHEMBL208542 | — | — | 1 | 5.66 |
| CHEMBL210985 | — | — | 1 | 5.47 |
| CHEMBL205799 | — | — | 1 | 4.66 |
| CHEMBL212269 | — | — | 1 | 4.62 |
| CHEMBL377750 | — | — | 1 | 4.60 |
| CHEMBL210953 | — | — | 1 | - |
| CHEMBL211998 | — | — | 1 | - |
| CHEMBL211035 | — | — | 1 | - |
| CHEMBL380042 | — | — | 1 | - |
| CHEMBL211601 | — | — | 1 | - |
| CHEMBL208541 | — | — | 1 | - |
| CHEMBL384680 | — | — | 1 | - |
| CHEMBL210123 | — | — | 1 | - |
| CHEMBL377906 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208901 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL208846 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL209163 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL209148 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL209881 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL379114 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL380058 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL210248 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL211291 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL379478 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL211842 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL382362 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL210932 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL208542 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL210985 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL205799 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL212269 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL377750 | — | IC50 | = | 25320.0 | nM | 4.60 |
| CHEMBL210953 | — | IC50 | - | — | - | |
| CHEMBL211998 | — | IC50 | - | — | - | |
| CHEMBL211035 | — | IC50 | - | — | - | |
| CHEMBL380042 | — | IC50 | - | — | - | |
| CHEMBL211601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL208541 | — | IC50 | - | — | - | |
| CHEMBL384680 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL210123 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL377906 | — | IC50 | > | 10000.0 | nM | - |