Assay Detail

CHEMBL864194

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ADMET

Inhibition of CYP450 2C9

ChEMBL ↗

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Target

Cytochrome P450 2C9 (CHEMBL3397) ↗

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Cytochrome P450 2C9 (CHEMBL3397) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2C9

CHEMBL3397

Anchored from Assay target.

Protein identity Cytochrome P450 2C9

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 2C9 (CHEMBL3397) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.

Hall A, Atkinson S, Brown SH, Chessell IP, Chowdhury A, Clayton NM, Coleman T, Giblin GM, Gleave RJ, Hammond B, Healy MP, Johnson MR, Michel AD, Naylor A, Novelli R, Spalding DJ, Tang SP.
Bioorg Med Chem Lett (2006) 16 : 3657 -3662
PubMed 16697196 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.41	5.41

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL208791	—	—	1	5.41

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL208791	—	IC50	=	3900.0	nM	5.41