Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL864291

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamase
28
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Stenotrophomonas maltophilia
Confidence 9 — Direct single protein target
Curated By Expert

Target

Beta-lactamase L1 (CHEMBL3326)
Type SINGLE PROTEIN
Organism Stenotrophomonas maltophilia

Publication

Homo-cysteinyl peptide inhibitors of the L1 metallo-beta-lactamase, and SAR as determined by combinatorial library synthesis.
Sun Q, Law A, Crowder MW, Geysen HM.
Bioorg Med Chem Lett (2006) 16 : 5169 -5175
PubMed 16875814 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 6.76 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL215590 3 8.68
CHEMBL217877 1 7.92
CHEMBL386173 2 7.92
CHEMBL385145 1 7.58
CHEMBL385485 2 6.85
CHEMBL385075 1 6.82
CHEMBL387406 1 6.80
CHEMBL215297 1 6.70
CHEMBL214517 1 6.70
CHEMBL215784 2 6.64
CHEMBL386485 1 6.58
CHEMBL214518 1 6.54
CHEMBL387290 1 6.54
CHEMBL214771 1 6.46
CHEMBL387243 1 6.41
CHEMBL386339 1 6.28
CHEMBL216052 1 6.27
CHEMBL384344 1 6.24
CHEMBL213608 1 6.11
CHEMBL214569 1 6.11
CHEMBL214330 1 6.06
CHEMBL384297 1 5.99
CHEMBL425101 1 5.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL215590 Ki = 2.1 nM 8.68
CHEMBL215590 Ki = 5.8 nM 8.24
CHEMBL386173 Ki = 12.0 nM 7.92
CHEMBL217877 Ki = 12.0 nM 7.92
CHEMBL385145 Ki = 26.0 nM 7.58
CHEMBL386173 Ki = 120.0 nM 6.92
CHEMBL215590 Ki = 130.0 nM 6.89
CHEMBL385485 Ki = 140.0 nM 6.85
CHEMBL385485 Ki = 140.0 nM 6.85
CHEMBL385075 Ki = 150.0 nM 6.82
CHEMBL387406 Ki = 160.0 nM 6.80
CHEMBL214517 Ki = 200.0 nM 6.70
CHEMBL215297 Ki = 200.0 nM 6.70
CHEMBL215784 Ki = 230.0 nM 6.64
CHEMBL215784 Ki = 230.0 nM 6.64
CHEMBL386485 Ki = 260.0 nM 6.58
CHEMBL387290 Ki = 290.0 nM 6.54
CHEMBL214518 Ki = 290.0 nM 6.54
CHEMBL214771 Ki = 350.0 nM 6.46
CHEMBL387243 Ki = 390.0 nM 6.41
CHEMBL386339 Ki = 520.0 nM 6.28
CHEMBL216052 Ki = 540.0 nM 6.27
CHEMBL384344 Ki = 570.0 nM 6.24
CHEMBL213608 Ki = 780.0 nM 6.11
CHEMBL214569 Ki = 780.0 nM 6.11
CHEMBL214330 Ki = 880.0 nM 6.06
CHEMBL384297 Ki = 1030.0 nM 5.99
CHEMBL425101 Ki = 3670.0 nM 5.43