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Compound Detail

CHEMBL386339

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C[Si](C)(C)CCC(=O)NC(CCS)C(=O)N[C@H](Cc1ccccc1)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL386339
Phase Preclinical
Structure Type MOL
InChI Key KTDLQAYOOWUVHY-OEMAIJDKSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

410.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H30N2O4SSi
MW 410.61

Activity Summary

Ki 1 meas. best 6.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-lactamase L1
CHEMBL3326
 Ki 6.28 6.28 520.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Beta-lactamase L1 Ki = 520.0 nM 6.28 Inhibition of Stenotrophomonas maltophilia L1 metallo beta lactamase 16875814

Literature References

PubMed DOI Target Context # Activities
16875814 10.1016/j.bmcl.2006.07.001 Beta-lactamase L1 2

Data from ChEMBL 36 via Core Engine