Assay Detail
Binding
CHEMBL864402
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Inhibition of 17beta-HSD3
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
17-beta-hydroxysteroid dehydrogenase type 3 (CHEMBL4234) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 7.45 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206432 | — | — | 1 | 10.70 |
| CHEMBL206384 | — | — | 1 | 10.70 |
| CHEMBL206167 | — | — | 1 | 10.70 |
| CHEMBL204882 | — | — | 1 | 9.15 |
| CHEMBL206405 | — | — | 1 | 9.05 |
| CHEMBL383546 | — | — | 1 | 8.85 |
| CHEMBL206331 | — | — | 1 | 8.70 |
| CHEMBL382563 | — | — | 1 | 8.70 |
| CHEMBL205426 | — | — | 1 | 8.52 |
| CHEMBL206217 | — | — | 1 | 8.52 |
| CHEMBL204349 | — | — | 1 | 8.52 |
| CHEMBL205666 | — | — | 1 | 8.40 |
| CHEMBL205915 | — | — | 1 | 8.30 |
| CHEMBL205144 | — | — | 1 | 8.15 |
| CHEMBL202916 | — | — | 1 | 8.10 |
| CHEMBL206250 | — | — | 1 | 8.10 |
| CHEMBL203947 | — | — | 1 | 8.05 |
| CHEMBL204051 | — | — | 1 | 8.00 |
| CHEMBL205373 | — | — | 1 | 7.60 |
| CHEMBL202967 | — | — | 1 | 7.52 |
| CHEMBL206181 | — | — | 1 | 7.30 |
| CHEMBL383270 | — | — | 1 | 7.16 |
| CHEMBL206768 | — | — | 1 | 7.05 |
| CHEMBL203237 | — | — | 1 | 7.05 |
| CHEMBL206535 | — | — | 1 | 7.00 |
| CHEMBL382624 | — | — | 1 | 6.85 |
| CHEMBL202841 | — | — | 1 | 6.80 |
| CHEMBL204877 | — | — | 1 | 6.62 |
| CHEMBL555150 | — | — | 1 | 6.62 |
| CHEMBL204104 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206432 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL206167 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL206384 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL204882 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL206405 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL383546 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL206331 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL382563 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL205426 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL206217 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL204349 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL205666 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL205915 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL205144 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL206250 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL202916 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL203947 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL204051 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL205373 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL202967 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL206181 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL383270 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL203237 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL206768 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL206535 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL382624 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL202841 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL204877 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL555150 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL204104 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL205145 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL383817 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL205762 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL204507 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL205914 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL206058 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL204765 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL202743 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL205664 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL206781 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL381769 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL379909 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL205556 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL205769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202915 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL204937 | — | IC50 | > | 1000.0 | nM | - |