Assay Detail
Binding
CHEMBL864474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5HT from human SERT expressed in COS7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.59 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42553 | — | — | 1 | 7.92 |
| CHEMBL198842 | — | — | 1 | 6.64 |
| CHEMBL196760 | — | — | 1 | 6.41 |
| CHEMBL216773 | — | — | 1 | 6.15 |
| CHEMBL372378 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42553 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL198842 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL196760 | — | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL216773 | — | Ki | = | 705.0 | nM | 6.15 |
| CHEMBL372378 | — | Ki | = | 1490.0 | nM | 5.83 |