Assay Detail
Binding
CHEMBL864530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from recombinant human mu opioid receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.22 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311157 | [11C]-CARFENTANIL | 1.0 | 1 | 10.15 |
| CHEMBL200456 | — | — | 1 | 9.89 |
| CHEMBL196960 | — | — | 1 | 9.89 |
| CHEMBL371710 | — | — | 1 | 9.13 |
| CHEMBL200392 | — | — | 1 | 8.92 |
| CHEMBL197479 | — | — | 1 | 8.68 |
| CHEMBL371268 | — | — | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311157 | [11C]-CARFENTANIL | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL200456 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL196960 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL371710 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL200392 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL197479 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL371268 | — | Ki | = | 13.5 | nM | 7.87 |