Assay Detail
Binding
CHEMBL864799
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Displacement of [3H]R-PIA from adenosine A2A receptor in rat brain striatal membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.11 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418333 | — | — | 1 | 5.85 |
| CHEMBL8488 | — | — | 1 | 4.85 |
| CHEMBL8565 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418333 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL8488 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL8565 | — | Ki | = | 24000.0 | nM | 4.62 |