Assay Detail
Binding
CHEMBL864940
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Inhibition of Akt1 in presence of 10 uM ATP
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.37 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379300 | A-443654 | — | 1 | 9.80 |
| CHEMBL210403 | — | — | 1 | 8.96 |
| CHEMBL383264 | — | — | 1 | 8.70 |
| CHEMBL208790 | — | — | 1 | 8.68 |
| CHEMBL210740 | — | — | 1 | 8.49 |
| CHEMBL211018 | — | — | 1 | 8.46 |
| CHEMBL263510 | — | — | 1 | 8.18 |
| CHEMBL211827 | — | — | 1 | 8.17 |
| CHEMBL210349 | — | — | 1 | 8.08 |
| CHEMBL207338 | — | — | 1 | 8.08 |
| CHEMBL379218 | — | — | 1 | 7.96 |
| CHEMBL208606 | — | — | 1 | 7.26 |
| CHEMBL211865 | — | — | 1 | 7.20 |
| CHEMBL211186 | — | — | 1 | 7.15 |
| CHEMBL437122 | — | — | 1 | 7.07 |
| CHEMBL210020 | — | — | 1 | 7.05 |
| CHEMBL379868 | — | — | 1 | 6.73 |
| CHEMBL212098 | — | — | 1 | 6.71 |
| CHEMBL378870 | — | — | 1 | 6.63 |
| CHEMBL378759 | — | — | 1 | 6.61 |
| CHEMBL211084 | — | — | 1 | 6.54 |
| CHEMBL212259 | — | — | 1 | 6.43 |
| CHEMBL207373 | — | — | 1 | 6.33 |
| CHEMBL212157 | — | — | 1 | 6.20 |
| CHEMBL209638 | — | — | 1 | 6.17 |
| CHEMBL209358 | — | — | 1 | 5.82 |
| CHEMBL208612 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379300 | A-443654 | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL210403 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL383264 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL208790 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL210740 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL211018 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL263510 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL211827 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL210349 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL207338 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL379218 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL208606 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL211865 | — | Ki | = | 63.7 | nM | 7.20 |
| CHEMBL211186 | — | Ki | = | 70.6 | nM | 7.15 |
| CHEMBL437122 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL210020 | — | Ki | = | 89.6 | nM | 7.05 |
| CHEMBL379868 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL212098 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL378870 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL378759 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL211084 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL212259 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL207373 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL212157 | — | Ki | = | 626.0 | nM | 6.20 |
| CHEMBL209638 | — | Ki | = | 672.0 | nM | 6.17 |
| CHEMBL209358 | — | Ki | = | 1525.0 | nM | 5.82 |
| CHEMBL208612 | — | Ki | = | 3282.0 | nM | 5.48 |