Compound Detail
CHEMBL379868
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Basic Information
| ChEMBL ID | CHEMBL379868 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NRBLWRZCVUTONX-NRFANRHFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
409.5
MW (Da)
4.43
ALogP
5
HBA
2
HBD
89.7
PSA (Ų)
0.43
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | Ki | 6.73 | 6.73 | 185.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | Ki | = | 185.0 | nM | 6.73 | Inhibition of Akt1 in presence of 10 uM ATP | 16678413 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16678413 | 10.1016/j.bmcl.2006.04.046 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine