Assay Detail
Binding
CHEMBL865447
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Inhibition of bovine brain mitochondrial MAOA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of N,N'-bis[2-oxo-2H-benzopyran]-3-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.40 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212501 | — | — | 1 | 9.00 |
| CHEMBL212068 | — | — | 1 | 8.40 |
| CHEMBL212069 | — | — | 1 | 7.79 |
| CHEMBL213141 | — | — | 1 | 7.48 |
| CHEMBL212555 | — | — | 1 | 6.77 |
| CHEMBL378988 | — | — | 1 | 6.74 |
| CHEMBL211141 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212501 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL212068 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL212069 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL213141 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL212555 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL378988 | — | Ki | = | 181.97 | nM | 6.74 |
| CHEMBL211141 | — | Ki | = | 2398.83 | nM | 5.62 |