Assay Detail
Binding
CHEMBL865639
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Inhibition of C1S
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 6.58 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205904 | — | — | 1 | 8.00 |
| CHEMBL377090 | — | — | 1 | 7.70 |
| CHEMBL438807 | — | — | 1 | 7.52 |
| CHEMBL377281 | — | — | 1 | 7.52 |
| CHEMBL382350 | — | — | 1 | 7.40 |
| CHEMBL206020 | — | — | 1 | 7.30 |
| CHEMBL381771 | — | — | 1 | 7.16 |
| CHEMBL382443 | — | — | 1 | 7.00 |
| CHEMBL205385 | — | — | 1 | 7.00 |
| CHEMBL426490 | — | — | 1 | 6.80 |
| CHEMBL205804 | — | — | 1 | 6.77 |
| CHEMBL381097 | — | — | 1 | 6.77 |
| CHEMBL205342 | — | — | 1 | 6.75 |
| CHEMBL380315 | — | — | 1 | 6.70 |
| CHEMBL377934 | — | — | 1 | 6.68 |
| CHEMBL438267 | — | — | 1 | 6.62 |
| CHEMBL204679 | — | — | 1 | 6.51 |
| CHEMBL205578 | — | — | 1 | 6.48 |
| CHEMBL205657 | — | — | 1 | 6.48 |
| CHEMBL205354 | — | — | 1 | 6.42 |
| CHEMBL379523 | — | — | 1 | 6.40 |
| CHEMBL380325 | — | — | 1 | 6.40 |
| CHEMBL205698 | — | — | 1 | 6.40 |
| CHEMBL204889 | — | — | 1 | 6.40 |
| CHEMBL380318 | — | — | 1 | 6.39 |
| CHEMBL204936 | — | — | 1 | 6.38 |
| CHEMBL382447 | — | — | 1 | 6.24 |
| CHEMBL205489 | — | — | 1 | 6.12 |
| CHEMBL382626 | — | — | 1 | 5.75 |
| CHEMBL380146 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205904 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL377090 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL438807 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL377281 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL382350 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL206020 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL381771 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL382443 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL205385 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL426490 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL205804 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL381097 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL205342 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL380315 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL377934 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL438267 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL204679 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL205578 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL205657 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL205354 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL379523 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL380325 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL205698 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL204889 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL380318 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL204936 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL382447 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL205489 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL382626 | — | Ki | = | 1790.0 | nM | 5.75 |
| CHEMBL380146 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL383619 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL383083 | — | Ki | = | 2240.0 | nM | 5.65 |
| CHEMBL208449 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL377438 | — | Ki | = | 11000.0 | nM | 4.96 |