Assay Detail
Binding
CHEMBL865967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to mu opioid receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.13 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501451 | — | — | 1 | 9.80 |
| CHEMBL458631 | — | — | 1 | 9.80 |
| CHEMBL208683 | — | — | 1 | 9.34 |
| CHEMBL2375157 | — | — | 1 | 9.30 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 9.16 |
| CHEMBL377392 | — | — | 1 | 8.83 |
| CHEMBL211543 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501451 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL458631 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL208683 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL2375157 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL377392 | — | Ki | = | 1.48 | nM | 8.83 |
| CHEMBL211543 | — | Ki | = | 19.9 | nM | 7.70 |