Assay Detail
Binding
CHEMBL866055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of L[3H]glutamate from GluR in rat brain synaptic membrane
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.38 | 6.48 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212694 | — | — | 1 | 6.48 |
| CHEMBL193486 | — | — | 1 | 5.42 |
| CHEMBL197084 | TROFINETIDE | 4.0 | 2 | 5.10 |
| CHEMBL379934 | — | — | 1 | - |
| CHEMBL211553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212694 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL193486 | — | Ki | = | 3790.0 | nM | 5.42 |
| CHEMBL197084 | TROFINETIDE | Ki | = | 7960.0 | nM | 5.10 |
| CHEMBL197084 | TROFINETIDE | Ki | = | 31240.0 | nM | 4.50 |
| CHEMBL379934 | — | Activity | - | — | - | |
| CHEMBL211553 | — | Activity | - | — | - |