Compound Detail
CHEMBL193486
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Basic Information
| ChEMBL ID | CHEMBL193486 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | KNUZCBVWBGSPRA-IUCAKERBSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
329.4
MW (Da)
-0.85
ALogP
5
HBA
4
HBD
150.0
PSA (Ų)
0.47
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 5.42 | 5.42 | 3790.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 3790.0 | nM | 5.42 | Displacement of L-[3H]glutamate from N-methyl-D-aspartate glutamate receptor in ... | 15837309 |
| Glutamate NMDA receptor | Ki | = | 3790.0 | nM | 5.42 | Displacement of L[3H]glutamate from GluR in rat brain synaptic membrane | 16650992 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15837309 | 10.1016/j.bmcl.2005.03.015 | Glutamate NMDA receptor | 1 |
| 16650992 | 10.1016/j.bmcl.2006.04.033 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine