Assay Detail
Binding
CHEMBL829838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of L-[3H]glutamate from N-methyl-D-aspartate glutamate receptor in rat brain synaptic membranes
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197208 | — | — | 1 | 9.00 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.06 |
| CHEMBL193486 | — | — | 1 | 5.42 |
| CHEMBL84612 | — | — | 1 | 5.42 |
| CHEMBL197084 | TROFINETIDE | 4.0 | 2 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197208 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL193486 | — | Ki | = | 3790.0 | nM | 5.42 |
| CHEMBL84612 | — | Ki | = | 3830.0 | nM | 5.42 |
| CHEMBL197084 | TROFINETIDE | Ki | = | 7960.0 | nM | 5.10 |
| CHEMBL197084 | TROFINETIDE | Ki | = | 31240.0 | nM | 4.50 |