Assay Detail
Binding
CHEMBL866234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST-PDE4A
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.82 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380321 | — | — | 1 | 10.00 |
| CHEMBL382168 | — | — | 1 | 10.00 |
| CHEMBL377709 | — | — | 1 | 10.00 |
| CHEMBL383225 | — | — | 1 | 9.70 |
| CHEMBL209295 | — | — | 1 | 9.52 |
| CHEMBL206968 | — | — | 1 | 9.52 |
| CHEMBL207996 | — | — | 1 | 9.22 |
| CHEMBL208100 | — | — | 1 | 9.22 |
| CHEMBL378681 | — | — | 1 | 9.00 |
| CHEMBL380933 | — | — | 1 | 8.82 |
| CHEMBL379768 | — | — | 1 | 8.80 |
| CHEMBL208236 | — | — | 1 | 8.77 |
| CHEMBL208382 | — | — | 3 | 8.74 |
| CHEMBL207559 | — | — | 1 | 8.74 |
| CHEMBL206592 | — | — | 1 | 8.68 |
| CHEMBL383837 | — | — | 1 | 8.51 |
| CHEMBL208149 | — | — | 1 | 8.46 |
| CHEMBL204522 | — | — | 1 | 8.00 |
| CHEMBL207424 | — | — | 1 | 7.82 |
| CHEMBL207775 | — | — | 1 | 7.80 |
| CHEMBL210840 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380321 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL382168 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL377709 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL383225 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL206968 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL209295 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL207996 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL208100 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL378681 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL380933 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL379768 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL208236 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL208382 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL207559 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL206592 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL208382 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL383837 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL208149 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL204522 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL207424 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL208382 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL207775 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL210840 | — | IC50 | = | 78.0 | nM | 7.11 |