Assay Detail
Binding
CHEMBL866344
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Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells
35
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.26 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.41 |
| CHEMBL206472 | — | — | 1 | 8.95 |
| CHEMBL210791 | — | — | 3 | 8.91 |
| CHEMBL210147 | — | — | 1 | 8.78 |
| CHEMBL377101 | — | — | 1 | 8.37 |
| CHEMBL379616 | — | — | 1 | 8.31 |
| CHEMBL426127 | — | — | 1 | 8.22 |
| CHEMBL207960 | — | — | 1 | 8.09 |
| CHEMBL207745 | — | — | 1 | 8.07 |
| CHEMBL207625 | — | — | 1 | 7.97 |
| CHEMBL208307 | — | — | 1 | 7.94 |
| CHEMBL424693 | — | — | 1 | 7.47 |
| CHEMBL206790 | — | — | 1 | 7.24 |
| CHEMBL207420 | — | — | 1 | 7.18 |
| CHEMBL377871 | — | — | 1 | 7.07 |
| CHEMBL207676 | — | — | 1 | 6.94 |
| CHEMBL379403 | — | — | 1 | 6.83 |
| CHEMBL382439 | — | — | 1 | 6.77 |
| CHEMBL209711 | — | — | 1 | 6.75 |
| CHEMBL209712 | — | — | 1 | 6.67 |
| CHEMBL382555 | — | — | 1 | 6.52 |
| CHEMBL382579 | — | — | 1 | 6.51 |
| CHEMBL206471 | — | — | 1 | 6.33 |
| CHEMBL207959 | — | — | 1 | 6.32 |
| CHEMBL379413 | — | — | 1 | 6.32 |
| CHEMBL377809 | — | — | 1 | 6.31 |
| CHEMBL206419 | — | — | 1 | 6.23 |
| CHEMBL208802 | — | — | 1 | 6.21 |
| CHEMBL382050 | — | — | 1 | 6.15 |
| CHEMBL379096 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL206472 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL210791 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL210147 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL377101 | — | Ki | = | 4.27 | nM | 8.37 |
| CHEMBL379616 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL210791 | — | Ki | = | 5.48 | nM | 8.26 |
| CHEMBL426127 | — | Ki | = | 6.03 | nM | 8.22 |
| CHEMBL210791 | — | Ki | = | 7.71 | nM | 8.11 |
| CHEMBL207960 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL207745 | — | Ki | = | 8.51 | nM | 8.07 |
| CHEMBL207625 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL208307 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL424693 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL206790 | — | Ki | = | 57.8 | nM | 7.24 |
| CHEMBL207420 | — | Ki | = | 65.7 | nM | 7.18 |
| CHEMBL377871 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL207676 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL379403 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL382439 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL209711 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL209712 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL382555 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL382579 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL206471 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL207959 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL379413 | — | Ki | = | 483.0 | nM | 6.32 |
| CHEMBL377809 | — | Ki | = | 493.0 | nM | 6.31 |
| CHEMBL206419 | — | Ki | = | 589.0 | nM | 6.23 |
| CHEMBL208802 | — | Ki | = | 617.0 | nM | 6.21 |
| CHEMBL382050 | — | Ki | = | 714.0 | nM | 6.15 |
| CHEMBL379096 | — | Ki | = | 724.0 | nM | 6.14 |
| CHEMBL426861 | — | Ki | = | 1514.0 | nM | 5.82 |
| CHEMBL379504 | — | Ki | = | 2188.0 | nM | 5.66 |
| CHEMBL206686 | — | Ki | > | 10000.0 | nM | - |