Assay Detail
ADMET
CHEMBL866476
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Inhibition of CYP2D6 by supersome assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.67 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205129 | — | — | 1 | 6.00 |
| CHEMBL203805 | — | — | 1 | 5.70 |
| CHEMBL204705 | — | — | 1 | 5.30 |
| CHEMBL203604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205129 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL203805 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL204705 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL203604 | — | IC50 | > | 30000.0 | nM | - |