Assay Detail
Functional
CHEMBL866752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 52 | 6.79 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.00 |
| CHEMBL212058 | — | — | 1 | 9.00 |
| CHEMBL210506 | — | — | 1 | 9.00 |
| CHEMBL208792 | — | — | 1 | 9.00 |
| CHEMBL213512 | — | — | 1 | 9.00 |
| CHEMBL378856 | — | — | 1 | 8.70 |
| CHEMBL377229 | — | — | 1 | 8.52 |
| CHEMBL211780 | — | — | 1 | 7.92 |
| CHEMBL209487 | — | — | 1 | 7.60 |
| CHEMBL210171 | — | — | 1 | 7.43 |
| CHEMBL211437 | — | — | 1 | 7.35 |
| CHEMBL209524 | — | — | 1 | 7.35 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.30 |
| CHEMBL377039 | — | — | 1 | 7.24 |
| CHEMBL378177 | — | — | 1 | 7.19 |
| CHEMBL379301 | — | — | 1 | 6.99 |
| CHEMBL213513 | — | — | 1 | 6.95 |
| CHEMBL211630 | — | — | 1 | 6.80 |
| CHEMBL379559 | — | — | 1 | 6.78 |
| CHEMBL212622 | — | — | 1 | 6.71 |
| CHEMBL211676 | — | — | 1 | 6.66 |
| CHEMBL378948 | — | — | 1 | 6.62 |
| CHEMBL211892 | — | — | 1 | 6.58 |
| CHEMBL211832 | — | — | 1 | 6.31 |
| CHEMBL209523 | — | — | 1 | 6.13 |
| CHEMBL211781 | — | — | 1 | 6.13 |
| CHEMBL213028 | — | — | 1 | 5.96 |
| CHEMBL214370 | — | — | 1 | 5.88 |
| CHEMBL209925 | — | — | 1 | 5.85 |
| CHEMBL437689 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL213512 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL208792 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL212058 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL210506 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL378856 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL377229 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL211780 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL209487 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL210171 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL211437 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL209524 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL377039 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL378177 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL379301 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL213513 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL211630 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL379559 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL212622 | — | EC50 | = | 197.0 | nM | 6.71 |
| CHEMBL211676 | — | EC50 | = | 221.0 | nM | 6.66 |
| CHEMBL378948 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL211892 | — | EC50 | = | 265.0 | nM | 6.58 |
| CHEMBL211832 | — | EC50 | = | 489.0 | nM | 6.31 |
| CHEMBL211781 | — | EC50 | = | 747.0 | nM | 6.13 |
| CHEMBL209523 | — | EC50 | = | 743.0 | nM | 6.13 |
| CHEMBL213028 | — | EC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL214370 | — | EC50 | = | 1327.0 | nM | 5.88 |
| CHEMBL209925 | — | EC50 | = | 1398.0 | nM | 5.85 |
| CHEMBL437689 | — | EC50 | = | 1713.0 | nM | 5.77 |
| CHEMBL426512 | — | EC50 | = | 2361.0 | nM | 5.63 |
| CHEMBL213548 | — | EC50 | = | 2695.0 | nM | 5.57 |
| CHEMBL277505 | — | EC50 | = | 2775.0 | nM | 5.56 |
| CHEMBL377980 | — | EC50 | = | 2821.0 | nM | 5.55 |
| CHEMBL211728 | — | EC50 | = | 3248.0 | nM | 5.49 |
| CHEMBL211433 | — | EC50 | = | 4551.0 | nM | 5.34 |
| CHEMBL211855 | — | EC50 | = | 5039.0 | nM | 5.30 |
| CHEMBL213550 | — | EC50 | = | 5691.0 | nM | 5.25 |
| CHEMBL211261 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL209499 | — | EC50 | = | 8259.0 | nM | 5.08 |
| CHEMBL377587 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL377020 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL209477 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL379208 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL210064 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL379859 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL425253 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL211322 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL377895 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL213242 | — | EC50 | > | 10000.0 | nM | - |