Assay Detail
Binding
CHEMBL867191
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Displacement of [3H]paroxetine from SERT
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.61 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204199 | — | — | 1 | 9.28 |
| CHEMBL22183 | — | — | 1 | 8.78 |
| CHEMBL203821 | — | — | 1 | 8.38 |
| CHEMBL383422 | — | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204199 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL22183 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL203821 | — | Ki | = | 4.15 | nM | 8.38 |
| CHEMBL383422 | — | Ki | = | 10.28 | nM | 7.99 |