Assay Detail
Binding
CHEMBL867593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]deltorphin-II from delta opioid receptor in rat brain synaptosomal membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.84 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571492 | — | — | 1 | 10.66 |
| CHEMBL370399 | — | — | 1 | 10.22 |
| CHEMBL370398 | — | — | 1 | 10.04 |
| CHEMBL198800 | — | — | 1 | 10.02 |
| CHEMBL196774 | — | — | 1 | 9.97 |
| CHEMBL370197 | — | — | 1 | 9.91 |
| CHEMBL197185 | — | — | 1 | 9.89 |
| CHEMBL381874 | — | — | 1 | 9.81 |
| CHEMBL198646 | — | — | 1 | 9.80 |
| CHEMBL200890 | — | — | 1 | 9.79 |
| CHEMBL261905 | — | — | 1 | 9.54 |
| CHEMBL373668 | — | — | 1 | 9.49 |
| CHEMBL373192 | — | — | 1 | 8.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571492 | — | Ki | = | 0.022 | nM | 10.66 |
| CHEMBL370399 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL370398 | — | Ki | = | 0.092 | nM | 10.04 |
| CHEMBL198800 | — | Ki | = | 0.095 | nM | 10.02 |
| CHEMBL196774 | — | Ki | = | 0.107 | nM | 9.97 |
| CHEMBL370197 | — | Ki | = | 0.124 | nM | 9.91 |
| CHEMBL197185 | — | Ki | = | 0.129 | nM | 9.89 |
| CHEMBL381874 | — | Ki | = | 0.155 | nM | 9.81 |
| CHEMBL198646 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL200890 | — | Ki | = | 0.163 | nM | 9.79 |
| CHEMBL261905 | — | Ki | = | 0.287 | nM | 9.54 |
| CHEMBL373668 | — | Ki | = | 0.323 | nM | 9.49 |
| CHEMBL373192 | — | Ki | = | 1.53 | nM | 8.81 |