Assay Detail
Binding
CHEMBL869117
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Inhibition of Wistar rat brain FAAH
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.54 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184238 | URB-597 | 1.0 | 1 | 8.42 |
| CHEMBL376748 | — | — | 1 | 6.28 |
| CHEMBL213092 | — | — | 1 | 6.16 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 5.48 |
| CHEMBL209996 | — | — | 1 | 5.40 |
| CHEMBL209391 | — | — | 1 | 5.40 |
| CHEMBL380201 | — | — | 1 | 5.16 |
| CHEMBL377268 | — | — | 1 | 5.10 |
| CHEMBL213901 | — | — | 1 | 4.66 |
| CHEMBL379427 | — | — | 1 | 4.50 |
| CHEMBL379136 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184238 | URB-597 | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL376748 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL213092 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL209996 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL209391 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL380201 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL377268 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL213901 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL379427 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL379136 | — | IC50 | = | 44000.0 | nM | 4.36 |