Compound Detail
CHEMBL376748
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Basic Information
| ChEMBL ID | CHEMBL376748 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HIQUBTZOYOZSPC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
276.4
MW (Da)
3.70
ALogP
4
HBA
1
HBD
51.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 6.28 | 6.28 | 520.0 | 1 |
| Monoglyceride lipase CHEMBL3321 | IC50 | 4.51 | 4.51 | 31000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 520.0 | nM | 6.28 | Inhibition of Wistar rat brain FAAH | 16854070 |
| Monoglyceride lipase | IC50 | = | 31000.0 | nM | 4.51 | Inhibition of MGL-like activity in Wistar rat cerebellar membranes | 16854070 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16854070 | 10.1021/jm060394q | Monoglyceride lipase | 1 |
| 16854070 | 10.1021/jm060394q | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine