Assay Detail
Binding
CHEMBL869403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human mitochondrial isozyme CA VA
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.28 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.22 |
| CHEMBL199464 | — | — | 1 | 6.89 |
| CHEMBL1628004 | — | — | 1 | 6.89 |
| CHEMBL370159 | — | — | 1 | 6.82 |
| CHEMBL200673 | — | — | 1 | 6.80 |
| CHEMBL199493 | — | — | 1 | 6.15 |
| CHEMBL371870 | PHENYLDIFLUOROMETHANESULFONAMIDE | — | 1 | 6.11 |
| CHEMBL370854 | — | — | 1 | 6.01 |
| CHEMBL1628081 | — | — | 1 | 5.83 |
| CHEMBL198891 | — | — | 1 | 5.82 |
| CHEMBL369953 | PHENYLMETHANESULFONAMIDE | — | 1 | 5.80 |
| CHEMBL198913 | — | — | 1 | 5.07 |
| CHEMBL24259 | PHENYLSULFAMATE | — | 1 | - |
| CHEMBL11185 | — | — | 1 | - |
| CHEMBL122708 | EMATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL199464 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL1628004 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL370159 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL200673 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL199493 | — | Ki | = | 714.0 | nM | 6.15 |
| CHEMBL371870 | PHENYLDIFLUOROMETHANESULFONAMIDE | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL370854 | — | Ki | = | 982.0 | nM | 6.01 |
| CHEMBL1628081 | — | Ki | = | 1464.0 | nM | 5.83 |
| CHEMBL198891 | — | Ki | = | 1516.0 | nM | 5.82 |
| CHEMBL369953 | PHENYLMETHANESULFONAMIDE | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL198913 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL24259 | PHENYLSULFAMATE | Ki | - | — | - | |
| CHEMBL11185 | — | Ki | - | — | - | |
| CHEMBL122708 | EMATE | Ki | - | — | - |