Assay Detail
Functional
CHEMBL869505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX1 in human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.03 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435298 | ESFLURBIPROFEN | 4.0 | 1 | 5.70 |
| CHEMBL190083 | TARENFLURBIL | 3.0 | 1 | 4.36 |
| CHEMBL380853 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435298 | ESFLURBIPROFEN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL190083 | TARENFLURBIL | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL380853 | — | IC50 | > | 100000.0 | nM | - |