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Assay Detail

CHEMBL869596

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP2C9
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cytochrome P450 2C9 (CHEMBL3397)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.
Guile SD, Bantick JR, Cheshire DR, Cooper ME, Davis AM, Donald DK, Evans R, Eyssade C, Ferguson DD, Hill S, Hutchinson R, Ingall AH, Kingston LP, Martin I, Martin BP, Mohammed RT, Murray C, Perry MW, Reynolds RH, Thorne PV, Wilkinson DJ, Withnall J.
Bioorg Med Chem Lett (2006) 16 : 2260 -2265
PubMed 16455256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.61 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378405 1 6.70
CHEMBL379399 1 6.70
CHEMBL205845 1 6.70
CHEMBL205526 1 6.30
CHEMBL205807 1 5.85
CHEMBL208487 1 5.77
CHEMBL204772 1 5.60
CHEMBL380192 1 5.58
CHEMBL204476 1 5.22
CHEMBL205245 1 5.06
CHEMBL426851 1 4.96
CHEMBL207100 1 4.89
CHEMBL205742 1 4.80
CHEMBL205092 1 4.46
CHEMBL85752 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378405 IC50 = 200.0 nM 6.70
CHEMBL379399 IC50 = 200.0 nM 6.70
CHEMBL205845 IC50 = 200.0 nM 6.70
CHEMBL205526 IC50 = 500.0 nM 6.30
CHEMBL205807 IC50 = 1400.0 nM 5.85
CHEMBL208487 IC50 = 1700.0 nM 5.77
CHEMBL204772 IC50 = 2500.0 nM 5.60
CHEMBL380192 IC50 = 2600.0 nM 5.58
CHEMBL204476 IC50 = 6000.0 nM 5.22
CHEMBL205245 IC50 = 8700.0 nM 5.06
CHEMBL426851 IC50 = 11000.0 nM 4.96
CHEMBL207100 IC50 = 13000.0 nM 4.89
CHEMBL205742 IC50 = 16000.0 nM 4.80
CHEMBL205092 IC50 = 35000.0 nM 4.46
CHEMBL85752 IC50 - -