Assay Detail
Binding
CHEMBL869872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.41 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.43 |
| CHEMBL214101 | — | — | 1 | 8.42 |
| CHEMBL213338 | — | — | 1 | 8.39 |
| CHEMBL296913 | PARECOXIB SODIUM | 4.0 | 1 | - |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL214101 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL213338 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL296913 | PARECOXIB SODIUM | IC50 | - | — | - | |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | - | — | - |