Assay Detail
Functional
CHEMBL869975
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Antiprotozoal activity against Trypanosoma cruzi epimastigotes
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 2 | - | - |
| IC50 | 2 | 6.45 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | 4.0 | 2 | 7.85 |
| CHEMBL633 | AMIODARONE | 4.0 | 2 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1397 | POSACONAZOLE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL633 | AMIODARONE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1397 | POSACONAZOLE | MIC | = | 20.0 | nM | - |
| CHEMBL633 | AMIODARONE | MIC | = | 20000.0 | nM | - |