Assay Detail
Binding
CHEMBL870198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.70 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209324 | — | — | 1 | 8.22 |
| CHEMBL2111058 | SUNEPITRON | 2.0 | 1 | 7.46 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 6.64 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 6.43 |
| CHEMBL209821 | NALUZOTAN | 3.0 | 1 | 5.80 |
| CHEMBL284092 | GEPIRONE | 4.0 | 1 | 5.62 |
| CHEMBL210537 | — | — | 1 | - |
| CHEMBL379984 | — | — | 1 | - |
| CHEMBL411941 | CYCLORGDFV | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209324 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2111058 | SUNEPITRON | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL49 | BUSPIRONE | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL209821 | NALUZOTAN | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL284092 | GEPIRONE | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL210537 | — | Ki | > | 3500.0 | nM | - |
| CHEMBL379984 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL411941 | CYCLORGDFV | Ki | - | — | - |