Assay Detail
ADMET
CHEMBL870679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP450 2C9
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel biaryl heterocyclic EP1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.32 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207293 | — | — | 1 | 5.72 |
| CHEMBL207174 | — | — | 1 | 5.41 |
| CHEMBL209244 | — | — | 1 | 5.37 |
| CHEMBL207577 | — | — | 1 | 5.24 |
| CHEMBL377852 | — | — | 1 | 5.19 |
| CHEMBL377649 | — | — | 1 | 5.17 |
| CHEMBL383090 | — | — | 1 | 5.14 |
| CHEMBL206096 | — | — | 1 | - |
| CHEMBL207688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207293 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL207174 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL209244 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL207577 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL377852 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL377649 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL383090 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL206096 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL207688 | — | IC50 | - | — | - |