Assay Detail
ADMET
CHEMBL870973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP450 3A4 transfected in human microsome using DEF fluorogenic substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.83 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208787 | — | — | 1 | 5.60 |
| CHEMBL377414 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208787 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL377414 | — | IC50 | = | 89000.0 | nM | 4.05 |